D-α-Hydroxyglutaric acid disodium- Hangzhou ROYALL Import & Export Co., Ltd.

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D-α-Hydroxyglutaric acid disodium

Purchase Qty: 1
Unit: Kg(s)
Fob Unit Price: US $200
Payment Terms:T/T

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Hangzhou ROYALL Import & Export Co., Ltd.

Business Type:Manufacturer

Country/Region:China

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HOT Rank

6/10

Product Information

Pharmacopeia:CP
Shelf Life:18 months
Storage:Sealed

Description

D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling.